Worldwide medical and scientific journal for animal health professionals

Issue number 28.1 Other Scientific

Cutaneous manifestations of systemic disease

Published 03/09/2020

Written by Patricia D. White

Also available in Français , Deutsch , Italiano , Polski , Русский and Español

Common diseases are seen commonly – but we must not forget that rare diseases can occur too. Here Patricia White describes some of the systemic diseases that can present with dermatologic signs, and offers some pointers for a diagnostic approach.

Cutaneous manifestations of systemic disease

Key Points

The limited ways in which the skin responds to disease may make cutaneous manifestations of systemic disease (CMSD) difficult to recognize.


Clinical signs that wax and wane with or without treatment, or fail to respond to appropriate therapy, should raise suspicion for a CMSD.


Certain distribution patterns and symmetry suggest an internal etiology, and abnormalities noted on general physical exam may be related to the dermatologic condition.


Clinical signs that wax and wane with or without treatment, or fail to respond to appropriate therapy, should raise suspicion for a CMSD.


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