Hypertriglyceridemia-associated proteinuria in Miniature Schnauzers
Proteinuria secondary to primary hypertriglyceridemia is a common yet under-recognized metabolic disorder of Miniature Schnauzers; Eva Furrow describes the diagnostic process and treatment options.
Primary hypertriglyceridemia is common in Miniature Schnauzers and is associated with proteinuria, glomerular lipid thromboemboli, and other glomerular pathology.
Affected dogs do not typically have azotemia or hypoalbuminemia; if these abnormalities are present, other causes of glomerular disease should be investigated.
Hyperadrenocorticism is a differential for hypertriglyceridemia and proteinuria and should be ruled out if consistent clinical signs or physical exam abnormalities are present.
Treatment involves dietary fat restriction and, if necessary, lipid-lowering drugs; proteinuria is managed with drugs that inhibit the renin-angiotensin-aldosterone system.